科学研究情况简介 |
【近年来获得的学术科研成果】 近年来在Biomaterials, ACS Applied Materials & Interfaces等期刊发表SCI论文30余篇。 【主要研究课题】 1. 中央高校基本科研重点项目，100万元 2. 国家自然科学基金青年基金，25万元 3. 江苏省自然科学基金面上项目，10万元 【近年来主要论文代表作】 [1] Wu J, Yan JY, Ye BT, Wu YL, Xu Z, Chen JH*, Chen JX*. Dual-responsive core crosslinking glycopolymer-drug conjugates nanoparticles for precise hepatocarcinoma therapy. Front Pharm, 2018, 9: 663. [2] Chen JX, Shi Y, Zhang YR, Teng LP, Chen JH. One-pot construction of boronate ester based pH-responsive micelle for combined cancer therapy. Colloids Surf B Biointerfaces, 2016, 143: 285-292. [3] Chen JX, Wang M, Tian HH, Chen JH. Hyaluronic acid and polyethylenimine self-assembled polyion complexes as pH-sensitive drug carrier for cancer therapy. Colloids Surf B Biointerfaces, 2015, 134: 81-87. [4] Chen JX, Xu XD, Chen WH, Zhang XZ. Multi-functional envelope-type nanoparticles assembled from amphiphilic peptidic prodrug with improved anti-tumor activity. ACS Appl Mater Interfaces, 2014, 6: 593-598. [5] Chen JX, Zhang M, Liu W, Lu Gz, Chen JH. Construction of serum resistant micelles based on heparosan for targeted cancer therapy. Carbohydr Polym, 2014, 110: 135-141. [6] Chen JX, Liu W, Zhang M, Chen JH*. Heparosan based negatively charged nanocarrier for rapid intracellular drug delivery. Int J Pharm, 2014, 473: 493-500. [7] Chen JX, Xu XD, Chen WH, Zhang XZ. Multi-functional envelope-type nanoparticles assembled from amphiphilic peptidic prodrug with improved anti-tumor activity. ACS Appl Mater Interfaces, 2014, 6: 593-598. [8] Chen JX, Xu XD, Yang S, Yang J, Zhuo RX, Zhang XZ. Self-assembled BolA-like amphiphilic peptides as viral-mimetic gene vectors for cancer cell targeted gene delivery. Macromol Biosci,2013, 13: 84-92. [9] Chen JX, Wang HY, Li C, Han K, Zhang XZ, Zhuo RX. Construction of surfactant-like tetra-tail amphiphilic peptide with RGD ligand and encapsulate porphyrin for photodynamic therapy. Biomaterials, 2011, 32: 1678-1684. [10] Chen JX, Wang HY, Quan CY, Xu XD, Zhang XZ, Zhuo RX. Amphiphilic cationic lipopeptides with RGD sequences as gene vectors. Org Biomol Chem, 2010, 8: 3142-3148. 【专利】 1. 一种具有自抗炎功能的胶原基海绵伤口辅料的制备方法，ZL201310123232.1 2. 一种抑菌并可促伤口修复壳聚糖水凝胶敷料的制备方法，201710705847.3 3. 一种双层型防水抑菌抗瘢痕壳聚糖海绵敷料的制备方法，201710705846.9 【主要奖励】 2018年教育部科技进步二等奖 |
