科学研究情况简介 |
【近年来获得的学术科研成果】 近年来发表SCI论文20余篇，主持多项国家自然科学基金和企业合作项目，申请发明专利8项。 【近年来主要研究课题】 [1]基于Heparosan多糖长循环多功能聚合物胶束的构建及作用机制研究，81503007，国家青年科学基金项目，主持。 [2]抗癌中药创新纳米制剂的制备及作用研究，2019M660166，中国博士后科学基金面上（一等资助）项目，主持。 [3] pH敏感靶向聚合物胶束及其逆转多药耐药的研究（JUSRP11565），中央高校基本科研业务经费培育项目，主持。 [4]胶原基修复凝胶的研发，企业项目，主持。 [5]缓释微丸的研发，企业项目，主持。 [6]玻尿酸冻干品的研发，企业项目，主持。 【近年来主要论文代表作】 [1]Qiu L, Qiao M, Chen Q, et al.Enhanced Effect of pH-Sensitive Mixed Copolymer Micelles for Overcoming Multidrug Resistance of Doxorubicin. Biomaterials. 2014, 35(37): 9877-9887. [2]Qiu L, Li Z, Qiao M, et al.Self-assembled pH-responsive Hyaluronic Acid-g-poly (L-histidine) Copolymer Micelles for Targeted Intracellular Delivery of Doxorubicin. Acta Biomaterialia. 2014, 10 (5): 2024-2035. [3]Qiu L, Hu Q, Cheng L, et al.cRGDyK modified pH responsive nanoparticles for specific intracellular delivery of doxorubicin. Acta Biomaterialia. 2016, 30: 285-298. [3] Chen Q, Long M,Qiu L*, et al.Decoration of pH-sensitive copolymer micelles with tumor-specific peptide for enhanced cellular uptake of doxorubicin. Int J Nanomedicine. 2016:11 5415–5427. [4]Qiu L, Zhu M, Huang Y, et al.Mechanisms of cellular uptake with hyaluronic acid-octadecylamine micelles as drug delivery nanocarriers. RSC advances, 2016, 6, 9896–39902. [5]Qiu L, Zhu M, Gong K, et al.pH-Sensitive degradable polymeric micelles for bio-triggered targeted anti-tumor drug delivery, Journal of Controlled Release. 2017, 259: e86-e87. [6]Qiu L, Zhu M, Gong K, et al.pH-triggered degradable polymeric micelles for targeted anti-tumor drug delivery. Mater Sci Eng C Mater Biol Appl. 2017, 78: 912-922. [7] Ahmed KS, Hussein SA, Ali AH, Korma SA,Lipeng Q*, Jinghua C*. Liposome: composition, characterisation, preparation, and recent innovation in clinical applications. J Drug Target. 2018, 15: 1-20. [8]Qiu L, Ge L, Long M, et al. Designing heparan sulfate-based biocompatible polymers and their application for intracellular stimuli-sensitive drug delivery. Mater Sci Eng C Mater Biol Appl. 2019, 94: 465-476. [9] Ahmed KS, Shan X, Mao J,Qiu L*, Chen J*. Derma roller® microneedles-mediated transdermal delivery of doxorubicin and celecoxib co-loaded liposomes for enhancing the anticancer effect.Mater Sci Eng C Mater Biol Appl.2019, 99:1448-1458. [10] Shan X, Mao J, Long M ,Ahmed KS, Sun C,Qiu L*, Chen J*. Influence of polyethylene glycol molecular weight on the anticancer drug delivery of pH-sensitive polymeric micelle.J Appl Polym Sci. 2019, 136 (32): 47854. [11]Qiu L, Shan X, Long M, et al. Elucidation of cellular uptake and intracellular trafficking of heparosan polysaccharide-based micelles in various cancer cells. Int J Biol Macromol. 2019, 130:755-764. [12] Ahmed KS, Sun C, Shan X, Mao J,Qiu L*, Chen J*. Liposome-based codelivery of celecoxib and doxorubicin hydrochloride as a synergistic dual-drug delivery system for enhancing the anticancer effect. J Liposome Res. 2019, 1-12. [13]Qiu L, Ge L, Long M, et al. Redox-responsive biocompatible nanocarriers based on novel heparosan polysaccharides for intracellular anticancer drug delivery. Asian J Pharm Sci. 2020, 15(1): 83-94. [14] Song JL, Huang ZQ, Mao J, Chen WJ, Wang B, Yang FW, Liu SH, Zhang HJ,Qiu LP*, Chen JH*. A facile synthesis of uniform hollow MIL-125 titanium-based nanoplatform for endosomal esacpe and intracellular drug delivery.Chem Eng J, 2020, 396: 125246. [15] Long M, Liu S, Shan X, Mao J, Yang F, Wu X, Qiu L*, Chen J*. Self-assembly of pH-sensitive micelles for enhanced delivery of doxorubicin to melanoma cells. J Drug Deliv Sci Tec, 2020, 59, 101859. [16] Maqsood M, Kang M, Wu X, Chen J, Teng L*, Qiu L*. Adult mesenchymal stem cells and their exosomes: Sources, characteristics, and application in regenerative medicine. Life Sci, 2020, 256, 118002. 【申请国家发明专利】 [1]一种复方坦洛新和非那雄胺控释片及制备方法.王东凯,邱立朋.公开号: CN 101703512A. [2]复方坦洛新和非那雄胺缓释胶囊及其制备方法.王东凯,邱立朋.公开号: CN101703511A. [3]一种坦洛新和非那雄胺复方缓释片及其制备方法.王东凯,邱立朋. CN 101703510A. [4]一种肝素前体多糖聚合物及其制备方法和应用.邱立朋,陈敬华,葛璐,毛静.公开号: CN201811562526.3. 【主要科研奖励】 全国挑战杯优秀指导教师 江南大学“青年至善学者” 高等学校科学研究技术进步二等奖 中国轻工业联合会科技进步二等奖 中国商业联合会科技进步一等奖 |
